Loureirin B
CAS No. 119425-90-0
Loureirin B ( Loureirin B; LR-B; L B; LRB )
Catalog No. M17868 CAS No. 119425-90-0
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
Purity : 98%
Size | Price / USD | Stock | Quantity |
5MG | 132 | In Stock |
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10MG | 196 | In Stock |
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25MG | 332 | In Stock |
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50MG | 489 | In Stock |
|
100MG | 698 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameLoureirin B
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NoteResearch use only, not for human use.
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Brief DescriptionLoureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
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DescriptionLoureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
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SynonymsLoureirin B; LR-B; L B; LRB
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number119425-90-0
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Formula Weight316.35
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Molecular FormulaC18H20O5
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Purity98%
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SolubilityDMSO : ≥ 150 mg/mL; 474.16 mM
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SMILESCOc1cc(c(c(c1)OC)CCC(=O)c1ccc(cc1)O)OC
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Chemical Name1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Myricetrin
Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
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Compound 3A
Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
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NSAH?
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.A unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affinity, inhibition, and cell toxicity assays.?NSAH binds to hRRM1 with an apparent dissociation constant of 37 μM, and steady-state kinetics reveal a competitive mode of inhibition.?