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Loureirin B

CAS No. 119425-90-0

Loureirin B ( Loureirin B; LR-B; L B; LRB )

Catalog No. M17868 CAS No. 119425-90-0

Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 196 In Stock
25MG 332 In Stock
50MG 489 In Stock
100MG 698 In Stock
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Biological Information

  • Product Name
    Loureirin B
  • Note
    Research use only, not for human use.
  • Brief Description
    Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
  • Description
    Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
  • Synonyms
    Loureirin B; LR-B; L B; LRB
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    119425-90-0
  • Formula Weight
    316.35
  • Molecular Formula
    C18H20O5
  • Purity
    98%
  • Solubility
    DMSO : ≥ 150 mg/mL; 474.16 mM
  • SMILES
    COc1cc(c(c(c1)OC)CCC(=O)c1ccc(cc1)O)OC
  • Chemical Name
    1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60.
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